Cancer Metabolism and Tumor Heterogeneity: Imaging Perspectives Using MR Imaging and Spectroscopy

Figure 5

Tumor oxygenation and microvascular permeability using Overhauser-enhanced MRI (OMRI). Comparison of maps of Gd-DTPA and OX63 (radical) in a squamous cell carcinoma (SCC). (a) SCC tumor region can be detected in a -weighted image by using 7-T MRI. (b) map of Gd-DTPA. (c) map of OX63 using OMRI of the same SCC tumor. Note OMRI/OX63 images were obtained before the 7-T MRI/Gd-DTPA study. (d) Corresponding pO₂ map computed from the same OMRI images for map. ((e), (f)) Based on the anatomical image, ROI of SCC tumor was selected and enlarged. Tumor region with low values (ROI 1) was relatively oxygenated and normal muscle tissue, and the region with high values (ROI 2) coincided with hypoxia in pO₂ image (adapted from [16]).