Brain Tumor Diagnostics and Therapeutics with Superparamagnetic Ferrite Nanoparticles

Figure 4

Characterization of Fe_xCo_1−xFe₂O₄ nanoparticles. (a) XRD (left) and TEM (from left to right) data of Fe_0.2Co_0.8Fe₂O₄ with bare nanoparticles as well as chitosan and PEG-coated nanoparticles, respectively. (b) Mössbauer spectra at room temperature for the compositions Fe_0.8Co_0.2Fe₂O₄ with NH₄OH coprecipitating agent (left), Fe_0.2Co_0.8Fe₂O₄ with NH₄OH coprecipitating agent (middle), and Fe_0.2Co_0.8Fe₂O₄ with NaOH coprecipitating agent (right). Slow relaxation is observed for and synthesized by NH₄OH and NaOH, respectively, as the coprecipitating agent, while other compositions showed mixture of slow/fast relaxation. (c) Heating profiles of Fe-Co mixed spinel ferrites at a concentration of 2 mg/mL of the nanoparticles in water for different compositions coated with chitosan (left) and PEG (middle). The right panel shows the concentration dependence of the nanoparticles in solution for mortality of 9L cells exposed to AMF-induced heating for 30 minutes with chitosan (gray) and PEG (blue) coating. From [10] with permission. See Table 1 for other details [10].

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