Brain Tumor Diagnostics and Therapeutics with Superparamagnetic Ferrite Nanoparticles

Figure 6

BIRDS-based mapping of different brain tumors at of 11.7 T. (a) Representative -weighted MRI with TmDOTP⁵⁻ (top row), CSI of protons on TmDOTP⁵⁻ (middle row), and map by BIRDS (bottom row) of rats bearing 9L, U87, and RG2 tumors during probenecid-TmDOTP⁵⁻ coinfusion. The tumor boundaries in CSI and BIRDS data (blue line) are from the MRI-defined region outlined by contrast enhancement arising from TmDOTP⁵⁻. From [20] with permission. (b) Representative maps from BIRDS in untreated (top) and temozolomide-treated (bottom) different rats bearing U251 tumors. The tumor boundary in BIRDS data (blue line) are from the MRI-defined region outlined by contrast enhancement arising from TmDOTP⁵⁻. From [21] with permission. (c) Representative maps from BIRDS before (top) and after (bottom) injection of SPIO-NPs in the same rat bearing an RG2 tumor. A SPIO-NPs dose of 7.3 mg/kg Fe³⁺ was injected systemically. The tumor boundaries in BIRDS data (blue line) are from the MRI-defined region outlined by contrast enhancement arising from SPIO-NPs dose of 1.7 mg/kg Fe³⁺ in the tumor. From [22] with permission.