Brain Tumor Diagnostics and Therapeutics with Superparamagnetic Ferrite Nanoparticles

Figure 7

Advanced GBM theranostics. Intracranial CED of D-NPs is used to deliver high concentration chemotherapy over prolonged periods directly into the tumor. However when intracranial CED of D-NPs is combined with F-NPs, MRI can be used to monitor the location of the chemotherapy. Alternatively, intracranial CED of F-NPs alone can be used to provide thermotherapy by AMF-induced heating. BIRDS, which requires systemic injection of an imaging agent, can measure responses to chemotherapy from D-NPs and thermotherapy from F-NPs, because BIRDS is unaffected by the superparamagnetic field gradients generated by F-NPs. The MRI and BIRDS data shown are from [22] with permission.