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Contrast Media & Molecular Imaging
Volume 2017 (2017), Article ID 7167292, 9 pages
https://doi.org/10.1155/2017/7167292
Clinical Study

Correlation of 18F-FDG PET/MRE Metrics with Inflammatory Biomarkers in Patients with Crohn’s Disease: A Pilot Study

1Department of Nuclear Medicine, Assuta Medical Centers and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
2IBD Center, Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel

Correspondence should be addressed to Liran Domachevsky; moc.liamg@arunaril

Received 25 May 2017; Accepted 3 August 2017; Published 19 September 2017

Academic Editor: Cristina Nanni

Copyright © 2017 Liran Domachevsky et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. J. M. Tolan, R. Greenhalgh, I. A. Zealley, S. Halligan, and S. A. Taylor, “MR enterographic manifestations of small bowel Crohn disease,” Radiographics, vol. 30, no. 2, pp. 367–384, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Cellier, T. Sahmoud, E. Froguel et al., “Correlations between clinical activity, endoscopic severity, and biological parameters in colonic or ileocolonic Crohn's disease. A prospective multicentre study of 121 cases,” Gut, vol. 35, no. 2, pp. 231–235, 1994. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Bouguen, B. G. Levesque, and B. G. Feagan, “Treat to target: a proposed new paradigm for the management of Crohn's disease,” Clinical Gastroenterology and Hepatology, vol. 13, no. 6, pp. 1042.e2–1050.e2, 2015. View at Publisher · View at Google Scholar
  4. S. Chang, L. Malter, and D. Hudesman, “Disease monitoring in inflammatory bowel disease,” World Journal of Gastroenterology, vol. 21, no. 40, pp. 11246–11259, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. B. C. Allen and J. R. Leyendecker, “MR enterography for assessment and management of small bowel Crohn disease,” Radiologic Clinics of North America, vol. 52, no. 4, pp. 799–810, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Masselli, M. Di Tola, E. Casciani et al., “Diagnosis of small-bowel diseases: Prospective comparison of multidetector row CT enterography with MR enterography1,” Radiology, vol. 279, no. 2, pp. 420–431, 2016. View at Publisher · View at Google Scholar · View at Scopus
  7. D. H. Bruining, G. Bhatnagar, J. Rimola, S. Taylor, E. M. Zimmermann, and J. G. Fletcher, “CT and MR enterography in Crohn’s disease: current and future applications,” Abdominal Imaging, vol. 40, no. 5, pp. 965–974, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. D. Groshar, H. Bernstine, D. Stern et al., “PET/CT enterography in Crohn disease: correlation of disease activity on CT enterography with18F-FDG uptake,” Journal of Nuclear Medicine, vol. 51, no. 7, pp. 1009–1014, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Beiderwellen, S. Kinner, B. Gomez et al., “Hybrid imaging of the bowel using PET/MR enterography: Feasibility and first results,” European Journal of Radiology, vol. 85, no. 2, pp. 414–421, 2016. View at Publisher · View at Google Scholar · View at Scopus
  10. G. Pellino, E. Nicolai, O. A. Catalano et al., “PET/MR versus PET/CT imaging: Impact on the clinical management of small-bowel Crohn's disease,” Journal of Crohn's and Colitis, vol. 10, no. 3, pp. 277–285, 2016. View at Publisher · View at Google Scholar · View at Scopus
  11. B. Huang, M. W.-M. Law, and P.-L. Khong, “Whole-body PET/CT scanning: estimation of radiation dose and cancer risk,” Radiology, vol. 251, no. 1, pp. 166–174, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Rimola, A. Alvarez-Cofiño, T. Pérez-Jeldres et al., “Comparison of three magnetic resonance enterography indices for grading activity in Crohn’s disease,” Journal of Gastroenterology, vol. 52, no. 5, pp. 585–593, 2016. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Iannicelli, I. Martini, C. Fantini et al., “Magnetic resonance enterography in Crohn's disease: New simple proposal to assess disease activity,” Clinical Imaging, vol. 40, no. 3, pp. 492–497, 2016. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Abej, W. El-Matary, H. Singh, and C. N. Bernstein, “The Utility of Fecal Calprotectin in the Real-World Clinical Care of Patients with Inflammatory Bowel Disease,” Canadian Journal of Gastroenterology and Hepatology, vol. 2016, Article ID 2483261, 2016. View at Publisher · View at Google Scholar · View at Scopus
  15. R. D'Incà and R. Caccaro, “Measuring disease activity in Crohn's disease: what is currently available to the clinician,” Clinical and Experimental Gastroenterology, vol. 7, no. 1, pp. 151–161, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Sipponen, C.-G. A. Bjrkesten, M. Färkkilä, H. Nuutinen, E. Savilahti, and K.-L. Kolho, “Faecal calprotectin and lactoferrin are reliable surrogate markers of endoscopic response during Crohn's disease treatment,” Scandinavian Journal of Gastroenterology, vol. 45, no. 3, pp. 325–331, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Vermeire, G. Van Assche, and P. Rutgeerts, “The role of C-reactive protein as an inflammatory marker in gastrointestinal diseases,” Nature Clinical Practice Gastroenterology & Hepatology, vol. 2, no. 12, pp. 580–586, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Karoui, S. Ouerdiane, M. Serghini et al., “Correlation between levels of C-reactive protein and clinical activity in Crohn's disease,” Digestive and Liver Disease, vol. 39, no. 11, pp. 1006–1010, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. M. H. Mosli, G. Zou, S. K. Garg et al., “C-reactive protein, fecal calprotectin, and stool lactoferrin for detection of endoscopic activity in symptomatic inflammatory bowel disease patients: A systematic review and meta-analysis,” American Journal of Gastroenterology, vol. 110, no. 6, pp. 802–819, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Bitton, P. L. Dobkin, M. D. Edwardes et al., “Predicting relapse in Crohn's disease: A biopsychosocial model,” Gut, vol. 57, no. 10, pp. 1386–1392, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Jürgens, J. M. M. John, I. Cleynen et al., “Levels of C-reactive protein are associated with response to infliximab therapy in patients with Crohn's disease,” Clinical Gastroenterology and Hepatology, vol. 9, no. 5, pp. 421.e1–427.e1, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Jones, E. V. Loftus Jr., R. Panaccione et al., “Relationships Between Disease Activity and Serum and Fecal Biomarkers in Patients With Crohn's Disease,” Clinical Gastroenterology and Hepatology, vol. 6, no. 11, pp. 1218–1224, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Lobatón, A. López-García, F. Rodríguez-Moranta, A. Ruiz, L. Rodríguez, and J. Guardiola, “A new rapid test for fecal calprotectin predicts endoscopic remission and postoperative recurrence in Crohn's disease,” Journal of Crohn's and Colitis, vol. 7, no. 12, pp. e641–e651, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. K. B. Gecse, J. F. Brandse, S. van Wilpe et al., “Impact of disease location on fecal calprotectin levels in Crohn's disease,” Scandinavian Journal of Gastroenterology, vol. 50, no. 7, pp. 841–847, 2015. View at Publisher · View at Google Scholar
  25. J. D. Lewis, “The utility of biomarkers in the diagnosis and therapy of inflammatory bowel disease,” Gastroenterology, vol. 140, no. 6, pp. 1817–1826, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Cerrillo, B. Beltrán, and S. Pous, “Fecal calprotectin in ileal Crohn's disease,” Inflammatory Bowel Diseases, vol. 21, no. 7, pp. 1572–1579, 2015. View at Publisher · View at Google Scholar
  27. N. Stanescu-Siegmund, Y. Nimsch, A. P. Wunderlich et al., “Quantification of inflammatory activity in patients with Crohn's disease using diffusion weighted imaging (DWI) in MR enteroclysis and MR enterography,” Acta Radiologica, vol. 58, no. 3, pp. 264–271, 2017. View at Publisher · View at Google Scholar · View at Scopus
  28. K.-J. Kim, Y. Lee, S. H. Park et al., “Diffusion-weighted MR enterography for evaluating Crohn's disease: How does it add diagnostically to conventional MR enterography?” Inflammatory Bowel Diseases, vol. 21, no. 1, pp. 101–109, 2015. View at Publisher · View at Google Scholar · View at Scopus
  29. H. A. Jacene, P. Ginsburg, J. Kwon et al., “Prediction of the need for surgical intervention in obstructive Crohn's disease by18F-FDG PET/CT,” Journal of Nuclear Medicine, vol. 50, no. 11, pp. 1751–1759, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. E. A. Russo, S. Khan, R. Janisch et al., “Role of 18F-fluorodeoxyglucose Positron Emission Tomography in the Monitoring of Inflammatory Activity in Crohn's Disease,” Inflammatory Bowel Diseases, vol. 22, no. 11, pp. 2619–2629, 2016. View at Publisher · View at Google Scholar · View at Scopus