Contrast Media & Molecular Imaging

Research Article

Comparison of 68Ga-DOTA-Siglec-9 and 18F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry

Table 2

Ex vivo biodistribution (% ID/g) of 68Ga-DOTA-Siglec-9 and 18F-FDR-Siglec-9 at 60 min after injection in rats with skin/muscle inflammation.
Organ68Ga-DOTA-Siglec-918F-FDR-Siglec-9  
Control area0.015
Inflamed area0.013
Adipose tissue, BAT0.12
Adipose tissue, WAT0.090
Blood0.33
Bone (femoral)0.67
Bone marrow0.022
Brain0.083
Heart0.0038
Kidneys0.0053
Liver0.00014
Lungs0.059
Muscle0.68
Pancreas0.00062
Plasma0.087
Small intestine0.051
Spleen0.0048
Testis0.45
Urine0.93
% ID/g = percentage of injected radioactivity dose per gram of tissue; BAT=brown adipose tissue; WAT = white adipose tissue. , 2-tailed Student’s -test.