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Contrast Media & Molecular Imaging
Volume 2017, Article ID 8650853, 11 pages
Research Article

The Spatial Relationship between Apparent Diffusion Coefficient and Standardized Uptake Value of 18F-Fluorodeoxyglucose Has a Crucial Influence on the Numeric Correlation of Both Parameters in PET/MRI of Lung Tumors

1University Hospital Basel, University of Basel, Clinic of Radiology & Nuclear Medicine, Petersgraben 4, 4031 Basel, Switzerland
2Diagnostic and Interventional Radiology, University Hospital Tübingen, Eberhard Karls University, Hoppe-Seyler-Straße 3, 72076 Tübingen, Germany
3University Hospital Basel, University of Basel, Clinic of Thoracic Surgery, Spitalstrasse 21, 4031 Basel, Switzerland
4Siemens Healthineers, Freilagerstrasse 40, 8047 Zürich, Switzerland

Correspondence should be addressed to Alexander W. Sauter; hc.bsu@retuas.rednaxela

Received 2 June 2017; Revised 18 September 2017; Accepted 2 October 2017; Published 17 December 2017

Academic Editor: Dinesh K. Deelchand

Copyright © 2017 Alexander W. Sauter et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The minimum apparent diffusion coefficient () derived from diffusion-weighted MRI (DW-MRI) and the maximum standardized uptake value () of FDG-PET are markers of aggressiveness in lung cancer. The numeric correlation of the two parameters has been extensively studied, but their spatial interplay is not well understood. After FDG-PET and DW-MRI coregistration, values and location of - and -voxels were analyzed. The upper limit of the 95% confidence interval for registration accuracy of sequential PET/MRI was 12 mm, and the mean distance () between - and -voxels was 14.0 mm (average of two readers). Spatial mismatch ( > 12 mm) between and was found in 9/25 patients. A considerable number of mismatch cases (65%) was also seen in a control group that underwent simultaneous PET/MRI. In the entire patient cohort, no statistically significant correlation between and was seen, while a moderate negative linear relationship () between and was observed in tumors with a spatial match ( ≤ 12 mm). In conclusion, spatial mismatch between and is found in a considerable percentage of patients. The spatial connection of the two parameters and has a crucial influence on their numeric correlation.