TY - JOUR
A2 - Kostikov, Alexey P.
AU - Joya, Ana
AU - Padro, Daniel
AU - Gómez-Vallejo, Vanessa
AU - Plaza-García, Sandra
AU - Llop, Jordi
AU - Martín, Abraham
PY - 2018
DA - 2018/12/02
TI - PET Imaging of Crossed Cerebellar Diaschisis after Long-Term Cerebral Ischemia in Rats
SP - 2483078
VL - 2018
AB - Crossed cerebellar diaschisis (CCD) is a decrease of regional blood flow and metabolism in the cerebellar hemisphere contralateral to the injured brain hemisphere as a common consequence of stroke. Despite CCD has been detected in patients with stroke using neuroimaging modalities, the evaluation of this phenomenon in rodent models of cerebral ischemia has been scarcely evaluated so far. Here, we report the in vivo evaluation of CCD after long-term cerebral ischemia in rats using positron emission tomography (PET) imaging with 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG). Imaging studies were combined with neurological evaluation to assess functional recovery. In the ischemic territory, imaging studies showed a significant decrease in glucose metabolism followed by a progressive recovery later on. Conversely, the cerebellum showed a contralateral hypometabolism from days 7 to 14 after reperfusion. Neurological behavior showed major impaired outcome at day 1 after ischemia followed by a significant recovery of the sensorimotor function from days 7 to 28 after experimental stroke. Taken together, these results suggest that the degree of CCD after cerebral ischemia might be predictive of neurological recovery.
SN - 1555-4309
UR - https://doi.org/10.1155/2018/2483078
DO - 10.1155/2018/2483078
JF - Contrast Media & Molecular Imaging
PB - Hindawi
KW -
ER -