Investigation of Newly Prepared Biodegradable 32P-chromic Phosphate-polylactide-co-glycolide Seeds and Their Therapeutic Response Evaluation for Glioma Brachytherapy
Bar graphs and SEM results of 32P-CP distribution in tumour and adjacent normal tissues at different time points after the intratumoural administration of SG and CG. (a) 32P-CP distribution in tumour and adjacent normal tissues at different time points in CG. The regional peak uptake in tumour tissues (t2) on day 16 was higher than day 8 (t1) (# means ) [t1, t2, and t3 indicate tumour tissues at different distance from the seed (SG) or the core of the tumour (CG), near to far, and “s” indicates tissues surrounding the tumour]. (b) 32P-CP distribution in tumour and adjacent normal tissues in the SG (significant difference between ti and t2, t2 and t3, and t3 and s, ) (c). SEM results of tumour and adjacent normal tissues (t1, t2, t3, and s). The 32P-CP particles are indicated with a black arrow. Irregularity of radioactivity distribution can be observed in the tumour and adjacent tissues in the CG, while a radioactivity gradient formed in the SG. The results were confirmed by SEM.