Presaturation Power Adjusted Pulsed CEST: A Method to Increase Independence of Target CEST Signals

Figure 4

The changes of the CEST signal are shown when the amplitude and duration of presaturation pulses were changed. All signals increase as either the amplitude or duration of the presaturation pulse is increased as expected, and the amplitude and duration pulse dependencies differ for each substance. The average increments of the signal per 1 µT through 2.3 µT to 5.5 µT for the substances are 0.4% in nicotinamide, 3.4% in glutamate, 0.5% in creatine, and 1.1% in glucose, respectively. Since the % change is somewhat higher for glutamate and glucose, these two substances are referred to as “amplitude-dependent.”