Exploiting the Concept of Multivalency with ⁶⁸Ga- and ⁸⁹Zr-Labelled Fusarinine C-Minigastrin Bioconjugates for Targeting CCK2R Expression

Table 2

Ex vivo biodistribution studies of ⁶⁸Ga-labelled mono- and multimers as well as ⁸⁹Zr-labelled counterparts in double tumour (±) xenografted BALB/C nude mice; data are presented as percentage of injected dose per gram tissue (% ID/g); mean () ± SD.

	^68Ga-labelled					^89Zr-labelled
	Monomer	Dimer	Trimer			Monomer	Dimer	Trimer
	1 h	1 h	1 h	2 h	4 h	1 h	1 h	1 h	2 h	4 h
Blood
Spleen
Pancreas
Stomach
Intestine
Kidneys
Liver
Heart
Lung
Muscle
Bone
A431-CCK2R
A431-mock

Statistical analysis was performed using the Student’s -test with values indicating significant () difference (a) between mono- and dimer, (b) between mono- and trimer, (c) between di- and trimer, (d) between ⁶⁸Ga-labelled tracers and corresponding ⁸⁹Zr-labelled counterparts, (e) between 1 h and 2 h, and (f) between 2 h and 4 h of radiolabelled trimer.