Exposure of Macrophages to Low-Dose Gadolinium-Based Contrast Medium: Impact on Oxidative Stress and Cytokines Production

<div>Cell viability of different types of gadolinium-based contrast agents (GBCAs) and gadolinium chloride on RAW 264.7 cells. Macrophages (RAW 264.7) were incubated in the absence or presence of 0.25, 0.83, and 2.5 <i>µ</i>M/mL of various GBCAs or Gd chloride for 24 h. The pH values of PBS diluted GBCAs were checked (a) (<i>n</i> = 3). The effect of GBCAs or Gd chloride on cell viability was determined by MTT assays immediately after incubation (b, c) (<i>n</i> = 3). Representative morphology recorded with a microscope after treatment with GBCAs for 24 h (d).</div>

Contrast Media & Molecular Imaging

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Figure 1

Figure 1: Exposure of Macrophages to Low-Dose Gadolinium-Based Contrast Medium: Impact on Oxidative Stress and Cytokines Production 