Radiomic Profiling of Head and Neck Cancer: ¹⁸F-FDG PET Texture Analysis as Predictor of Patient Survival

Table 3

Multivariate analysis of the patients’ dataset for PFS without (A) and including (B) imaging biomarkers. Harrel c-indexes of the models, which score their prognostic power, are 0.65 and 0.76, respectively. The two c-indexes are significantly different with a value of 0.01.

	value	HR	95% CI for HR
			Lower	Upper
(A)
Gender (F vs M)	0.713	1.191	0.469	3.026
Age	0.426	1.014	0.979	1.050
Stage (III vs IV)	0.160	1.894	0.777	4.617
Tumor site (oropharynx vs others)	0.902	0.953	0.445	2.042
CHT (No vs Yes)	0.176	0.489	0.173	1.378
(B)
Age	0.254	1.02E + 00	9.86E − 01	1.06E + 00
Stage (III vs IV)	0.440	1.43E + 00	5.77E − 01	3.55E + 00
CHT (No vs Yes)	0.012	2.03E − 01	5.84E − 02	7.06E − 01
Run percentage	0.176	1.97E − 01	1.87E − 02	2.07E + 00
LILRE	<0.001	1.41E − 83	4.05E − 128	4.90E − 39
Coarseness	0.970	4.12E − 01	2.32E − 21	7.33E + 19
Code similarity	0.129	4.27E − 23	5.77E − 52	3.16E + 06