In Vivo 6-([¹⁸F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity

Figure 4

IHC for AH2A, AH2B, AH3, and AH4 in the cerebral cortex. Original magnifications, upper: ×40, lower: ×200 in the parietal cortex. AH3 staining was suppressed in a dose-dependent manner in the cerebral cortex of mice in Groups A (Cis 2 mg/kg) and B (Cis 4 mg/kg) and was almost equal in Group C (Cis 4 mg/kg + SAHA 300 mg/kg) compared with a control mouse. Scale bar, 100 μm.