Contrast Media & Molecular Imaging / 2018 / Article / Tab 1

Research Article

Image-Guided Neutron Capture Therapy Using the Gd-DO3A-BTA Complex as a New Combinatorial Treatment Approach

Table 1

Various types of gadolinium agents for NCT.

FormInjection routeInjection amount (Gd)Tumor accumulation Gd/g tumorHighest uptake time (ICP time)Reference

Low moleculesGd-DTPAi.t.1200 µg/mouse451 µg/g5 min[7]
5.3 µg/g24 h
Gd-DTPAi.v.0.1 mmol/kg70.39 ± 8.75 µg/g5 min[8]
30.22 ± 4.91 µg/g2 h
Gd-BOPTAi.v.0.1 mmol/kg100.33 ± 7.91 µg/g5 min[8]
40.93 ± 1.83 µg/g2 h
Gd-DO3A-BTAi.v.0.1 mmol/kg221 µg/g6 h[9]

NanoparticlesLiposomei.v.N/D40.277 ± 2.512 µg/g2 h[10]
Liposomei.v.20 mg/kg158.8 ± 115.6 µg/g12 h[11, 12]
Lipid emulsionsi.p.6 mg/hamster107 µg/g48 h[13]
Micellesi.v.0.02 mmol/kg3.9% ID/ga10 h[14]
Lipid NPsi.v.6 mg/hamster100.7 µg/g12 h[15]
Chitosan NPsi.t.2.4 mg/mouseb1766 ± 96 µg/tumor tissuec8 h[16, 17]
Chitosan NPsi.t.1200 µg/mouse897.1 µg/g24 h[7]

N/D: not determined; i.t.: intratumoral; i.v.: intravenous; i.p.: intraperitoneal. a%ID/g: percentages of the total injected dose per organ weight. bAdministered twice by i.t. injection 24 h and 8 h before the assay. cThe Gd content in melanoma tissue in mice.

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