Isolated Perfused Rat Livers to Quantify the Pharmacokinetics and Concentrations of Gd-BOPTA

<div>Gd-BOPTA concentrations in hepatocytes over time (a) according to the concomitant Gd-BOPTA elimination rates from sinusoids to liver (<sub>SIN</sub>ELIMR<sub>LIVER</sub>, nmol/min) and Gd-BOPTA elimination rates from hepatocytes to bile canaliculi (<sub>HC</sub>ELIMR<sub>BC</sub>) (b). Two groups of rats are studied: normal rats (<i>n</i> = 5, black symbols) and rats lacking Mrp2 (<i>n</i> = 3, grey symbols). Livers are perfused with 200 <i>μ</i>M Gd-BOPTA (45 to 75 min) and rinse solution (75 to 105 min). Adapted from [<a href="/journals/cmmi/2018/3839108/#B14">14</a>] with permission.</div>

Contrast Media & Molecular Imaging

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Figure 7

Figure 7: Isolated Perfused Rat Livers to Quantify the Pharmacokinetics and Concentrations of Gd-BOPTA 