Contrast Media & Molecular Imaging

Review Article

In Vivo and In Vitro Characteristics of Radiolabeled Vesamicol Analogs as the Vesicular Acetylcholine Transporter Imaging Agents

Table 4

Accumulation of enantiomers of vesamicol analogs (1–18) in the striatum and cortex and the ratio of the striatum to cortex (ST/CTX) for enantiomers of radiolabeled vesamicol analogs.


	%ID/g			ST/CTX	Animal
	Cortex	Striatum	Whole brain	ST/CTX	Animal

(−)-[¹²⁵I]IBVM (1) [36]	2.56 (240 min)	6.26 (240 min)	—	2.44	Mouse
(+)-[¹²⁵I]IBVM (1) [36]	0.12 (240 min)	0.26 (240 min)	—	2.17	Mouse
(−)-[¹⁸F]FEOBV (2)^∗ [45]	4.5 (180 min)	9.0 (180 min)	—	1.74	Mouse
(+)-[¹⁸F]FEOBV (2)^∗ [45]	2.0 (180 min)	1.9 (45 min)	—	0.95	Mouse
(−)-[¹¹C]MABV (3)	3.99 (45 min)	8.1 (45 min)	—	2.03	Mouse
(+)-[¹¹C]MABV (3)	0.91 (45 min)	1.23 (45 min)	—	1.35	Mouse
(−)-[¹²⁵I]MIBT (8) [52]	—	—	0.27 (60 min)	—	Rat
(+)-[¹²⁵I]MIBT (8) [52]	—	—	0.83 (60 min)	—	Rat
(−)-[¹⁸F]FBT (9) [57]	1.18 (60 min)	1.03 (60 min)	1.05 (60 min)	0.87	Rat
(+)-[¹⁸F]FBT (9) [57]	0.58 (60 min)	0.74 (60 min)	0.59 (60 min)	1.28	Rat
(−)-[¹²³I]OIDV (13) [63]	0.62 (30 min)	0.63 (30 min)	—	1.02	Rat
(+)-[¹²³I]OIDV (13) [63]	0.46 (30 min)	0.45 (30 min)	—	0.98	Rat
(−)-[¹⁸F]FBBV (18) [77]	—	—	0.226 (30 min)	—	Rat
(+)-[¹⁸F]FBBV (18) [77]	—	—	0.071 (30 min)	—	Rat

The value that was read from a graph was used.