Sensitivity of Multiphase Pseudocontinuous Arterial Spin Labelling (MP pCASL) Magnetic Resonance Imaging for Measuring Brain and Tumour Blood Flow in Mice

Figure 2

Optimisation of MP pCASL bolus duration. (a) A−10° labelling plane (blue) relative to the axial imaging plane (yellow) was optimal, as this was perpendicular to the carotid and vertebral arteries visible by angiography (red). Label plane placement posterior to the medulla oblongata, visible on a sagittal T₂ weighted anatomical image (green), enabled consistent label plane location between animals, while not interfering with imaging slices (yellow). (b) No significant differences were found in calculated CBF across the range of label duration times tested ().

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(b)