Research Article

Sensitivity of Multiphase Pseudocontinuous Arterial Spin Labelling (MP pCASL) Magnetic Resonance Imaging for Measuring Brain and Tumour Blood Flow in Mice

Figure 7

Application of the MP pCASL sequence in mice with intracerebral U87 glioma at the day 28 time point. (a) T1-weighted image showing no evidence of gadolinium enhancement in the tumour injected (left) hemisphere. (b) Immunohistochemical image showing an overlay of tumour area (red) combined from tissue sections spanning 500 µm corresponding to the MRI slice in (a). (c) CBF maps showing reduction in local CBF (arrowheads) (d-e). Immunohistochemical image showing CD31 staining of vessels (brown) in tumour-injected striatum (d) and contralateral striatum (e). (f) Graph showing CBF values in the tumour-bearing (black) and contralateral (white) striatum. CBF is reduced in the tumour-bearing compared with the contralateral striatum at day 28 time point (). Scale bars = 20 µm.
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