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Contrast Media & Molecular Imaging
Volume 2018, Article ID 4898365, 9 pages
Research Article

Do TSH, FT3, and FT4 Impact BAT Visualization of Clinical FDG-PET/CT Images?

1Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), QST, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan
2Department of Radiology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake-cho, Miyazaki-shi, Miyazaki 889-1692, Japan
3Department of Radiology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan
4Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Graduate School of Medicine, No. 54, ShogoinKawahara-cho, Sakyo-ku, Kyoto, Kyoto 606-8507, Japan

Correspondence should be addressed to Ryuichi Nishii; pj.og.tsq@ihciuyr.iihsin

Received 12 September 2017; Revised 29 December 2017; Accepted 4 January 2018; Published 13 February 2018

Academic Editor: Chongzhao Ran

Copyright © 2018 Ryuichi Nishii et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. We retrospectively analyzed activated BAT visualization on FDG-PET/CT in patients with various conditions and TH levels to clarify the relationships between visualization of BAT on FDG-PET/CT and the effect of TH. Methods. Patients who underwent clinical FDG-PET/CT were reviewed and we categorized patients into 5 groups: (i) thyroid hormone withdrawal (THW) group; (ii) recombinant human thyrotropin (rhTSH) group; (iii) hypothyroidism group; (iv) hyperthyroidism group; and (v) BAT group. A total of sixty-two FDG-PET/CT imaging studies in fifty-nine patients were performed. To compare each group, gender; age; body weight; serum TSH, FT3, and FT4 levels; and outside temperature were evaluated. Results. No significant visualization of BAT was noted in any of the images in the THW, rhTSH, hypothyroidism, and hyperthyroidism groups. All patients in the BAT group were in a euthyroid state. When the BAT-negative and BAT-positive patient groups were compared, it was noted that the minimum and maximum temperature on the day of the PET study and maximum temperature of the one day before the PET study were significantly lower in BAT-positive group than in all those of other groups. Conclusions. Elevated TSH condition before RIT, hyperthyroidism, or hypothyroidism did not significantly impact BAT visualization of clinical FDG-PET/CT images.