Contrast Media & Molecular Imaging / 2018 / Article / Fig 6

Research Article

NIRF Optical/PET Dual-Modal Imaging of Hepatocellular Carcinoma Using Heptamethine Carbocyanine Dye

Figure 6

Tumor hypoxia and OATP3A1 mediate MHI-148 dye uptake in HCC. (a) H&E and IHC analyses of HIF1α and OATP1B3 protein expression in liver cancer tissues derived from three PDX models. Original magnification, ×400; scale bars represent 20 μm. (b) MHI-148 dye uptake by Hep3B cells with prior exposure to either hypoxia or OATP3A1-targeting siRNA. Representative images are shown. Original magnification, 400x; scale bar, 50 μm. (c) Oncomine analysis of select OATP transcript levels in different liver cancer data sets (normal versus cancer). .

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