Preclinical Evaluation of Radioiodinated Hoechst 33258 for Early Prediction of Tumor Response to Treatment of Vascular-Disrupting Agents

Figure 1

The chemical structure of H33258 (a) and radioactive HPLC profile of ¹³¹I-H33258 (b) and the corresponding profile of stability study (c). The arrows in (c) denote the peaks corresponding to intact tracer ¹³¹I-H33258 (10.01 min) and free iodine (2.97 min) after incubation in human serum at 37°C for 24 h.

(a)

(b)

(c)