A 51-year-old male patient with cirrhosis secondary to chronic HBV and HCC. DCE-MRI, IVIM (b = 400), and BOLD (TE = 30 ms, pre-O2) images and PET overlay on anatomical T2-weighted image demonstrate 3.8 cm HCC in the left liver lobe (white arrows). Plots of the DCE-MRI, IVIM, and BOLD data points (open circles) and fits (solid lines; SSM fit shown for DCE-MRI) are displayed in the panels at the bottom of the figure for liver (blue) and HCC (red) ROIs. The fitted parameters are shown next to the plots. The HCC lesion showed avid FDG uptake (SUVmean 6.06 and SUVmax 7.80) and relatively low perfusion/permeability as measured by DCE-MRI.