Contrast Media & Molecular Imaging / 2018 / Article / Tab 2

Research Article

Multiparametric FDG-PET/MRI of Hepatocellular Carcinoma: Initial Experience

Table 2

Average parameter values (mean ± SD) and diagnostic performance of multiparametric FDG-PET/MRI parameter values for differentiation between liver parenchyma and HCC lesions.

ParameterLiverHCCFDR-adj PAUCThresholdSens (%)Spec (%)

DCE-MRIKtrans TM (min−1)1.07 ± 0.941.62 ± 1.270.2850.612.3346.786.7
TM0.46 ± 0.290.58 ± 0.310.4660.600.5160.073.3
kep TM (min−1)2.96 ± 2.982.66 ± 1.890.9240.512.0573.360.0
ART TM0.50 ± 0.360.85 ± 0.190.0320.780.6086.766.7
Ktrans SSM (min−1)1.61 ± 0.901.91 ± 1.140.6170.552.5453.380.0
SSM0.58 ± 0.300.69 ± 0.290.4480.590.9140.080.0
kep SSM (min−1)3.80 ± 3.163.10 ± 1.800.6290.525.0540.093.3
ART SSM0.33 ± 0.330.74 ± 0.290.0060.810.5386.780.0
τi (s)0.27 ± 0.250.24 ± 0.170.9780.510.3233.380.0

IVIMD (10−3 mm2/s)1.34 ± 0.621.10 ± 0.270.5860.601.5135.792.8
D (10−3 mm2/s)27.8 ± 23.133.6 ± 26.50.5860.6232.750.078.6
PF0.30 ± 0.160.31 ± 0.140.8700.530.1792.921.4
ADC (10−3 mm2/s)2.02 ± 1.491.59 ± 0.460.5870.571.9350.085.7

BOLD pre-O2 (s−1)85.6 ± 53.450.8 ± 18.00.0160.7479.946.793.3
post-O2 (s−1)87.8 ± 51.650.2 ± 20.40.0160.7946.093.366.7
Δ (s−1)2.47 ± 5.98−1.14 ± 9.070.4200.583.7040.080.0

FDG-PETSUVmean2.01 ± 0.342.88 ± 1.310.4480.702.5646.7100
SUVmax2.40 ± 0.523.93 ± 2.020.0910.753.3553.3100

MultiparametricART SSM +  post-O20.13 ± 0.080.38 ± 0.17<0.0010.910.2773.3100

The values originate from Wilcoxon signed-rank tests. Significant values () are shown in bold. The number of lesions analyzed per method was as follows: DCE-MRI, 21 HCC lesions in 15 patients; IVIM, 18 HCC lesions in 14 patients; BOLD, 19 lesions in 15 patients. Represents the average of parameter values from multiple HCC lesions in patients with more than one lesion. ADC,  apparent diffusion coefficient; ART,  arterial fraction; AUC,  area under the curve; D,  diffusion coefficient; ,  pseudodiffusion coefficient; FDR,  false discovery rate; kep,  rate constant; Ktrans,  transfer constant; PF, perfusion fraction; ,  transverse relaxation rate; SSM,  shutter-speed model; SUV,  standard uptake value; τi, mean intracellular water molecule lifetime; TM,  Tofts model and ,  extravascular extracellular volume fraction.