Research Article
Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice
Figure 3
PET images (maximal intensity projections) of mice with (a) 13.9 MBq [11C]AM7 and (b) 12.5 MBq [11C]AM7 after cyclosporine administration (50 mg/kg i.v.). Radioactivity in the images () was normalized to /BW (standardized uptake value, SUV) and averaged for the complete scan duration of 60 min. G, gallbladder; H, heart; I, intestines; K, kidney; L, liver; U, urinary bladder. CD1 nu/nu mice.
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