Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice

Figure 5

SUV plasma curves of [¹¹C]AM7 and [¹¹C]MT107 as derived from the PET images. (a) Control (circles, []MT107, ; squares, [¹¹C]AM7, ). (b) After cyclosporine treatment ( for []MT107; for [¹¹C]AM7). Lines, biexponential fits according to (1). Colours distinguish individual data sets. Fit parameters; see Table 1.

(a)

(b)