Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model

Table 2

The summary of pharmacokinetic parameters of Gd-EOB-DTPA.

	Control	70% hepatectomy	90% hepatectomy
(μmol⋅min/L)	2501.0 ± 922.6	3956.6 ± 1067.2	9234.5 ± 3891.5
(μmol⋅min/L)	2659.6 ± 1099.2	4292.3 ± 1281.8	14199.8 ± 10949.0
(%)	5.1 ± 3.2	7.1 ± 3.3	24.7 ± 15.2
/dose (μmol⋅min/L/μmol)	90.1 ± 43.1	160.6 ± 49.0	545.0 ± 417.5
(μmol/L)	238.1 ± 62.4	264.1 ± 58.2	334.9 ± 65.6
/Dose (μmol/L/μmol)	8.0 ± 2.6	9.9 ± 2.3	12.9 ± 2.9
CL (ml/min)	12.7 ± 4.1	6.8 ± 2.3	2.7 ± 1.5
(mL)	269.7 ± 70.1	189.1 ± 36.0	142.1 ± 39.3
(mL)	487.7 ± 157.0	254.9 ± 62.1	160.6 ± 55.2
(min)	27.3 ± 5.9	27.0 ± 5.3	52.6 ± 30.2
(min)	15.6 ± 4.5	20.3 ± 4.5	48.1 ± 30.1

Data are presented as means ± standard deviation. : area under the serum concentration-time curve from time zero to time of last measurable concentration; : AUC from time zero to time extrapolated to infinite time; (%): AUC from time of last measurable concentration extrapolated time to infinite time/; : measured peak plasma concentration; CL: clearance; : steady-state volume of distribution; : terminal phase volume of distribution; : terminal half-life; : effective half-life.