Table 2: Calculated Ki-values of the bile acid analogues for NTCP, OATP1B1, and BSEP. Data are mean ± SD (n = 3). 3βFCA IC50-values were extracted from literature [13] and used to calculate the Ki-values.

Ki for NTCP (µM)Ki for OATP1B1 (µM)Ki for BSEP (µM)

CA12.96 ± 4.2642.70 ± 0.1695.46 ± 33.97
3αFCA2.53 ± 0.765.22 ± 0.56198.93 ± 39.47
3βFCA6.18 ± 0.599.67 ± 0.83216.30 ± 52.99
3βFGCA1.09 ± 0.344.24 ± 0.1687.38 ± 14.61
3βFCDCA0.91 ± 0.020.64 ± 0.0748.24 ± 3.94
12βFCA30.08 ± 9.404.56 ± 0.25367.02 ± 38.11