111In-DANBIRT In Vivo Molecular Imaging of Inflammatory Cells in Atherosclerosis
Neutrophil-specific LFA-1 targeting using radiolabeled DANBIRT. Adult rats were exposed to filtered air or ozone for 4 hours, and blood components were isolated afterwards. An acute increase of neutrophils was evidenced uniquely when exposed to ozone (a). Increased uptake was seen in neutrophils and decreased uptake was seen in RBC's after ozone exposure. Wright-Giemsa staining was used in blood smears which particularly evidenced a predominance of immature neutrophils (b) in ozone-exposed rats. One-way ANOVA with multiple comparisons was used for statistical analysis (;) (n of 3 per group).
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