Comparative Evaluation of Radioiodine and Technetium-Labeled DARPin 9_29 for Radionuclide Molecular Imaging of HER2 Expression in Malignant Tumors

Table 4

Comparison of [¹²⁵I]I-DARPin 9_29 and [^99mTc]Tc(CO)₃- DARPin 9_29 tumor-to-organ ratios in nude mice bearing SKOV-3 xenografts.

	Tumor-to-organ ratio
	[^125I]I-DARPin 9_29	[^99mTc]Tc(CO)3-DARPin 9_29
Blood	3.4 ± 1.8	3.4 ± 0.5
Salivary glands	2.0 ± 0.7	2.0 ± 0.4
Lung	4 ± 2	1.7 ± 0.4
Liver	3 ± 1	0.11 ± 0.02∗
Spleen	4 ± 1	0.35 ± 0.04
Stomach	1.2 ± 1.0	2.1 ± 0.5
Kidney	1.00 ± 0.16	0.035 ± 0.003
Muscle	11.3 ± 5.5	6.6 ± 2.6
Bone	4.4 ± 0.9	1.6 ± 0.4

Significant difference () between values for [¹²⁵I]I-DARPin 9_29 and [^99mTc]Tc(CO)₃-DARPin 9_29. Data are presented as mean ± SD for four mice.