Construction and Evaluation of the Tumor-Targeting, Cell-Penetrating Multifunctional Molecular Probe iCREKA

Figure 3

Fluorescent confocal imaging of cell internalization of FITC-iCREKA and FITC-CREKA in the fixed U87 glioma cells ((a) and (b)). (a) Cell internalization of FITC-iCREKA in the presence and in the absence of MMP-2 (green, (A), (A1)), staining of nucleus (blue, (B), (B1)), and merged image of FITC-iCREKA uptake and nucleus ((C), (C1)). (b) Cell internalization of FITC-CREKA in the presence and in the absence of MMP-2 (green, (A), (A1)), staining of nucleus (blue, (B), (B1)), and merged image of FITC-CREKA uptake and nucleus ((C), (C1)). Magnification: ×60.

(a)

(b)