Iso-Osmolar Iodixanol Induces Less Increase in Circulating Endothelial Microparticles In Vivo and Less Endothelial Apoptosis In Vitro Compared with Low-Osmolar Iohexol

Figure 1

Effects of iodixanol and iohexol on circulating levels of CD31⁺/CD41a⁻ EMPs, CD62E⁺ EMPs, and PMPs. Gating of microparticles (a). The flow cytometry was referenced by calibration beads (size in 0.2 μm and 1.0 μm) (A). Acquisition of PBS, which was filtered by a filter in 0.22 μm (B). Events between 0.1 μm and 1.0 μm in size on FS-SS graph were gated as microparticles (C). Measurement of plasma EMPs and PMPs at baseline and after injection of iodixanol or iohexol during PCI in patients with stable coronary artery disease (b–d). Staining of microparticles with CD31-FITC and CD41a-APC (b) and CD62E-PE (c), and results of CD31⁺CD41a⁻ EMP, CD62E⁺ EMP, and PMPs in 3 groups (d). The data were expressed as mean ± SD. DM: diabetes mellitus; NDM: non-diabetes mellitus; NS: nonsignificant; PCI: percutaneous coronary intervention. , , and .

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