Contrast Media & Molecular Imaging / 2018 / Article / Fig 4

Research Article

Thyroid Cancer Detection by Ultrasound Molecular Imaging with SHP2-Targeted Perfluorocarbon Nanoparticles

Figure 4

Target molecular imaging in vivo experiments after LIFU irradiation 1.40 w/cm2 for 20 min. (a) Different ultrasound images mode following the injection of SHP2-signed contrast nanoparticles showing a high signal in thyroid tumour and showing only background signal when using nontargeted contrast nanoparticles. (b) A bar graph summarizing the quantitative signal obtained using ultrasound imaging with SHP2-signed and nontargeted nanoparticles in a thyroid cancer mouse model; a significantly increased imaging signal was observed in the SHP2-targeted nanoparticles compared to the nontargeted nanoparticles in the tumour tissue. .

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