Single-Chain Variable Fragment Antibody of Vascular Cell Adhesion Molecule 1 as a Molecular Imaging Probe for Colitis Model Rabbit Investigation

Figure 2

The characteristics of colitis model rabbit. (a) Photos of the model rabbit (left) and the control rabbit (right). The contamination on the foot of the model rabbit indicated diarrhea symptom. (b) Photos of stool in the rectum of the model rabbit (upper) and the control rabbit (lower). Model group stool confirmed diarrhea manifestation. (c) The model colon (left) developed macroscopic colitis with hemorrhagic spots, while the control group (right) kept smooth and intact mucosa. (d) Pictures of model colon (upper) and control colon (lower) HE staining. The blue arrow indicated ulcer and inflammation in the mucous layer of the model colon. (e) The daily changes of model rabbits during 7 days of colitis induction were expressed as trend curves for parameters of body weight, platelet (PLT), white blood cell (WBC), red blood cell (RBC), and hemoglobin (HGB) (mean ± SD, ).

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