Multifunctionalized Microscale Ultrasound Contrast Agents for Precise Theranostics of Malignant Tumors

Figure 3

Schematics of porphyrin microbubbles (pMBs) and their micro-to-nanoconversion: (a) pMBs consist of a BChl-lipid shell encapsulating perfluorocarbon gas; (b) conversion of pMBs to porphyrin nanoparticles (pNPs) via sonication with low-frequency, high-duty-cycle ultrasound (conversion ultrasound) (reprinted with permission from the Springer Nature [71]; permission conveyed through Copyright Clearance Center, Inc).

(a)

(b)