^99mTc-Radiolabeled TPGS Nanomicelles Outperform ^99mTc-Sestamibi as Breast Cancer Imaging Agent

Figure 2

(a) ^99mTc-sestamibi and ^99mTc-radiolabeled TPGS micelles cellular uptake (4T1 cell line). Results are expressed as the percentage of activity accumulated in the cellular fraction normalized by 10⁶ cells. (b) ^99mTc-sestamibi and ^99mTc-radiolabeled TPGS micelles biodistribution in a breast cancer animal model developed with 4T1 murine cell line in BALB/c mice. Results are expressed as the percentage of injected dose in each organ normalized by organ weight (%ID/g). Bars represent mean ± SD. (c) Gamma camera imaging of ^99mTc-radiolabeled TPGS micelles (12 h after injection) and ^99mTc-sestamibi (15 min after injection) in a breast cancer animal model developed with 4T1 murine cell line in BALB/c mice. Green arrows indicate the palpable tumoral site. Representative images are shown. Mice outline was drawn for anatomical references.

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