Synthesis and Evaluation of ¹⁸F-Labeled Peptide for Gonadotropin-Releasing Hormone Receptor Imaging

Figure 3

HPLC analysis the stability of [¹⁸F]FP-D-Lys⁶-GnRH: (a) [¹⁸F]FP-D-Lys⁶-GnRH incubation in PBS and bovine serum for 2 h compared to [¹⁸F]FP-D-Lys⁶-GnRH from the quality control and its reference standard FP-D-Lys⁶-GnRH; (b) representative HPLC profiles displaying unchanged [¹⁸F]FP-D-Lys⁶-GnRH (peak 3) and its metabolites (peak 1, peak 2, and peak 4) in PC-3 tumors at 1 h after intravenous injection in the blocking group. ret. = retention time in min.

(a)

(b)