Cellular MRI Reveals Altered Brain Arrest of Genetically Engineered Metastatic Breast Cancer Cells

Figure 3

Differences in endpoint metastatic burden between naïve and engineered 4T1BR5 cells: representative MR slices from each group, and brain metastases indicated by white arrowheads ( per group) (a). BLI signal was detected in the brain and body of mice that received luciferase-expressing cells () (b). The number of brain metastases (c) and total brain tumour burden (d) in mice that received naïve and luciferase-expressing 4T1BR5 cells. The ratio of the number of tumours at endpoint over the number of signal voids on day 0 was also compared between groups (e). The data are presented as mean ± SEM.

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