T2 Relaxation Time Obtained from Magnetic Resonance Imaging of the Liver Is a Useful Parameter for Use in the Construction of a Murine Model of Iron Overload

Table 1

Hemoglobin levels and iron indices in the blood on Day 3 after administration of iron-dextran or dextran (control = dextran group; Iron 0.1 = 0.1 mg iron-dextran/mouse; Iron 0.5 = 0.5 mg iron-dextran/mouse; Iron 2.5 = 2.5 mg iron-dextran/mouse).

	Control	Iron 0.1	Iron 0.5	Iron 2.5
Hemoglobin (g/dL)	15.0 ± 1.1	15.3 ± 1.6	15.8 ± 1.5	14.3 ± 0.6
Serum iron (μg/dL)	152.8 ± 42.7	182.8 ± 46.8	143.6 ± 27.2	184.6 ± 22.0
UIBC (μg/dL)	120.0 ± 13.0	121.8 ± 22.2	140.8 ± 24.3	130.6 ± 30.4
TIBC (μg/dL)	272.8 ± 35.7	304.6 ± 45.8	284.4 ± 26.9	315.2 ± 27.2

Mean ± SD (n = 5); UIBC, unsaturated iron binding capacity; TIBC, total iron binding capacity.