Biodistribution of [¹¹C]-Metformin and mRNA Expression of Placentae Metformin Transporters in the Pregnant Chinchilla

Figure 1

Transport of metformin across the placenta barrier depends on both influx transporters and efflux transporters. Influx and efflux transporters on both sides are necessary for bidirectional transport across the placenta. The placenta barrier of humans and chinchillas is called hemomonochorial because the maternal and fetal blood are divided by only one layer of syncytiotrophoblasts.