Contrast Media & Molecular Imaging / 2020 / Article / Fig 3

Clinical Study

Relationship between SP142 PD-L1 Expression and 18F-FDG Uptake in Non-Small-Cell Lung Cancer

Figure 3

The correlation between maximum standardized uptake value (SUVmax) and programmed cell death ligand-1 (PD-L1) expression. (a) In NSCLC, the SUVmax values of PD-L1-negative (<1%), -low expressing (1%–49%), and -high-expressing (>50%) tumors were 8.22 ± 5.77, 11.63 ± 6.18, and 15.52 ± 7.72, respectively. (b) In ADC, the SUVmax values of PD-L1-negative (<1%), -low expressing (1%–49%), and -high-expressing (>50%) tumors were 7.21 ± 5.15, 9.24 ± 5.25, and 12.91 ± 6.41, respectively. (c) In SCC, the SUVmax values of PD-L1-negative (<1%), -low expressing (1%–49%), and -high-expressing (>50%) tumors were 14.25 ± 4.85, 15.90 ± 5.75, and 18.87 ± 8.59, respectively. Receiver operating characteristic curve analysis of the ability of SUVmax to predict PD-L1 expression levels. The area under the curve for non-small-cell lung cancer (d), adenocarcinoma (e), and squamous cell carcinoma (f) was 0.726 (95% confidence interval 0.679–0.774; ), 0.694 (95% confidence interval 0.634–0.755; ), and 0.625 (95% confidence interval 0.513–0.738; ), respectively.
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