MnDPDP: Contrast Agent for Imaging and Protection of Viable Tissue

Figure 10

MnDPDP: myocardial remodeling in a patient examined 3 weeks after AMI treated with pPCI [19]. One hour after i.v. infusion of MnDPDP (5 μmol/kg, 5 min) T₁WI shows a transmural infarct in the LV lateral wall and an apparent thickening of remote myocardium. LV maps of SWT (mm) and of R₁ (s⁻¹) show parallel directions of rising values from the infarct towards remote sectors. Myocardial Mn²⁺ uptake (arbitrary units (a.u.)) over 30 min is biphasic in remote sectors and monophasic and smaller in the infarct. LV ejection fraction (LVEF): 48%. Reproduced with permission from J Magn Reson Imaging.