Review Article

MnDPDP: Contrast Agent for Imaging and Protection of Viable Tissue

Figure 11

MnDPDP: myocardial remodeling—sectorial R1 (T1) vs. systolic wall thickening (SWT) [19]. Mapping of SWT and R1 at 1.5 T was undertaken in 24 sectors of LV myocardium before (native reference) and one hour after i.v. infusion of MnDPDP (5 μmol/kg, 5 min). Data were obtained from 10 patients undergoing remodeling after AMI. (a) Measured values of R1 (s−1) vs. SWT (mm) before and after MnDPDP. Dotted black lines are drawn at SWT 0 and 5 mm; blue and red lines are drawn between mean R1 values at 0 and 5 mm SWT. In spite of large spread in individual R1 values, significant correlations were found between infarct-to-remote directional angles for SWT and R1 both before and after MnDPDP. Figure reproduced with permission from J Magn Reson Imaging. (b) Diagram based on values from (a) but presented as T1 (ms) vs. SWT (range 0–5 mm). The dotted horizontal lines mark T1 of normal myocardium [17, 18]. T1-SWT correlations are marked by continuous lines. Blue line: native T1 values (1150–1040 ms). Red line: T1 values after MnDPDP (900–740 ms).