Review Article

MnDPDP: Contrast Agent for Imaging and Protection of Viable Tissue

Figure 4

Dual contrast imaging with IC Mn and EC Gd in infarcted rat myocardium. Rats with permanently ligated left coronary artery underwent single session cardiac MRI at 7.0 T. The figure displays T1 maps of LV myocardium: Native; Mn (MnCl2 infusion (25 μmol/kg)); and Mn + Gd (gadodiamide injection 150 μmol/kg)). At the end of the experiment, Gd was obtained by late (10 min) Gd-enhancement and subtraction technique (T1WI). T1 values in msec (mean (SD)) are included. IC Mn adducts lower T1 mainly, but not exclusively, in viable cardiomyocytes whereas EC located gadodiamide lowers T1 and raises SI mainly inside infarcted tissue (Bruvold M, Seland JG, Jynge P, unpublished data 2006).