Distinguishing Lymphomatous and Cancerous Lymph Nodes in 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography by Radiomics Analysis

Table 3

The results of ROC analysis of potentially optimal radiomic parameters in PET and CT images.

LLN versus CLN				HLLN versus CLN				NHLLN versus CLN				HLLN versus NHLLN
Radiomic parameters in CT image	AUC	Radiomic parameters in PET image	AUC	Radiomic parameters in CT image	AUC	Radiomic parameters in PET image	AUC	Radiomic parameters in CT image	AUC	Radiomic parameters in PET image	AUC	Radiomic parameters in CT image	AUC	Radiomic parameters in PET image	AUC
CTvalue_min_CT	0.88	NGLDM_Coarseness_PET	0.89	CTvalue_min_CT	0.94	NGLDM_Coarseness _PET	0.88	CTvalue_min_CT	0.87	NGLDM_Coarseness _PET	0.85	HISTO_Kurtosis_CT	0.73	Age	0.67
GLZLM_ZLNU_CT	0.86	GLZLM_LZHGE_PET	0.87	HISTO_Entropy_log2 _CT	0.93	GLZLM_LZHGE_PET	0.87	CTvalue_std_CT	0.86	FDGuptake_TLG (mL) _PET	0.83	NGLDM_Contrast_CT	0.70	GLZLM_SZE_PET	0.63
HISTO_Entropy_log2_CT	0.86	SHAPE_Volume (mL)_PET	0.86	HISTO_Entropy_log10 _CT	0.93	GLCM_Entropy_log2 _PET	0.87	HISTO_Entropy_log2_CT	0.85	SHAPE_Volume (mL) _PET	0.83	Age	0.67	FDGuptake_SUVmin _PET	0.63
HISTO_Entropy_log10_CT	0.86	SHAPE_Volume (vx) _PET	0.86	HISTO_Energy_CT	0.93	GLCM_Entropy_log10 _PET	0.87	HISTO_Entropy_log10 _CT	0.85	SHAPE_Volume (vx) _PET	0.83	GLCM_Homogeneity _CT	0.66	GLZLM_SZHGE_PET	0.61
GLCM_Entropy_log10_CT	0.85	FDGuptake_TLG (mL) _PET	0.86	GLCM_Entropy_log10 _CT	0.93	GLCM_Energy_PET	0.87	GLCM_Entropy_log10 _CT	0.84	GLRLM_RLNU_PET	0.82	HISTO_Skewness_CT	0.65	GLRLM_LRLGE_PET	0.61
GLCM_Entropy_log2_CT	0.85	GLRLM_RLNU_PET	0.86	GLCM_Entropy_log2_CT	0.93	FDGuptake_TLG (mL) _PET	0.87	HISTO_Energy_CT	0.84	SHAPE_Compacity _PET	0.82	GLCM_Energy_CT	0.64	GLZLM_LZLGE_PET	0.61

Abbreviations: AUC, area under the ROC curve; ROC, receiver operating characteristics; LLN, lymphomatous-lymph nodes; CLN, cancerous-lymph nodes; HLLN, LLN caused by Hodgkin’s lymphoma; NHLLN, LLN caused by non-Hodgkin’s lymphoma; PREct, CT-predictive variables; PREpet, PET-predictive variables; PREcombination, the combination of PET and CT predictive variables. HISTO, histogram; GLCM, gray-level co-occurrence matrix; GLRLM, gray-level run-length matrix; HGRE, high gray-level run emphasis; GLZLM, gray-level zone-length matrix; HGZE, high gray-level zone emphasis; RLNU, run-length nonuniformity; LZHGE, long-zone high gray-level emphasis; min, minimum; std, standard error; _CT, parameter extracted from the CT image; _PET, parameter extracted from the PET image.