Longitudinal GluCEST MRI Changes and Cerebral Blood Flow in 5xFAD Mice

Figure 4

Chronological changes in CBF of 5xFAD and WT mice in corresponding ROIs as those in T2WI images in Figure 3. CBF in all regions except for the striatum significantly decreases in 5xFAD mice by 7 months of age. In WT mice, CBF in the hippocampus and thalamus decreased by 10 months of age, whereas all other ROIs had identical values throughout the study. The number in parentheses indicates the number of analyzed mice. , compared with 1-month-old mice. ^†p > 0.05, ^††p > 0.01 compared with WT mice.

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