Research Article
Preclinical Molecular PET-CT Imaging Targeting CDCP1 in Colorectal Cancer
Figure 3
CDCP1-targeted molecular PET-CT imaging detects CDCP1-expressing patient-derived CRC13 model in mice. (a) Representative image of H&E stained (left) and anti-CDCP1 immunohistochemical staining (right) demonstrating moderate plasma membrane staining of CDCP1 on malignant cells in subcutaneous CRC13 xenograft tumors in mice (magnification 40X; scale bar 50 μm_. (b) Representative 3D PET-CT imaging reconstructions of mice bearing subcutaneous CRC13 tumors administered i.v.89Zr-10D7 or 89Zr-IgG1κ (1MBq) at 1, 24, 48, 72, and 144 h after administration. (c) Graph of the time course of in vivo PET avidity of CRC13 tumors at 1, 24, 48, 72, and 144 h after i.v. administration of 89Zr-10D7 and 89Zr-IgG1κ. (d) Graph of radioactivity of recovered tumors, organs, and blood by ex vivo radiometric analysis and displayed as %ID/g. , ; , ; , .
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