Diagnostic Accuracy of Combined PET/CT with MRI, 18F-FDG PET/MRI, and 18F-FDG PET/CT in Patients with Oropharyngeal and Hypopharyngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Table 2

Diagnostic performance of combined MRI with PET/CT, PET MRI, and PET/CT in patients with synchronous cancers and distant metastases in patients with oropharyngeal and hypopharyngeal squamous cell carcinomas.

Parameter	PET/CT	PET/MRI	Combined PET/CT with MRI
Sensitivity (95% CI)	0.79 (95% CI 72%–85%)	0.80 (95% CI 69%–87%)	0.92 (95% CI 76%–97%)
Specificity (95% CI)	0.88(95% CI 83%–92%)	0.91 (95% CI 79%–96%)	0.93 (95% CI 74%–98%)
PLR (95% CI)	8.95 (95% CI 4.21–19.03)	9.64 (95% CI 3.93–23.64)	13.22 (95% CI 3.36–52.06)
NLR (95% CI)	0.10 (95% CI 0.05–0.19)	0.21 (95% CI 0.14–0.32)	0.08 (95% CI 0.02–0.26)
DOR (95% CI)	85.51 (95% CI 39.43–185.46)	44.41 (95% CI 20.17–97.78)	160.52 (95% CI 44.81–575)
PPV	0.85	0.84	0.82
NPV	0.95	0.89	0.99
Accuracy	0.87 (95% CI 83%–91%)	0.92 (95% CI 90%–93%)	0.94 (95% CI 92%–97%)
AUC-SROC
I^2	72.7%	57.4%	93.4%
Q index	7.15	7.32	30.11