Change of Apoptosis and Glucose Metabolism in Lung Cancer Xenografts during Cytotoxic and Anti-Angiogenic Therapy Assessed by Annexin V Based Optical Imaging and ¹⁸F-FDG-PET/CT

Figure 2

Molecular imaging of apoptosis. (a) Quantitative analysis demonstrates a significantly higher accumulation of AnnexinVivo at day 9 after therapy start with carboplatin (). (b) In sunitinib-treated tumors, AnnexinVivo accumulation also increases continuously; however, differences to the controls are not significant. (c) Linear regression analysis of the accumulation of AnnexinVivo during carboplatin treatment showing a significant increase in the accumulation of AnnexinVivo over time (R² = 0.26, slope: 6.91, ). (d) Linear regression analysis of the accumulation of AnnexinVivo during sunitinib treatment. An increase in the accumulation of AnnexinVivo is visible over time, though not significant (R² = 0.15, slope: 6.88, ). (e) Representative FMT/µCT hybrid images (transverse plane) showing the signal of AnnexinVivo in the tumor of an untreated control animal and in tumors of carboplatin and sunitinib-treated animals at day 4 and day 9. The accumulation of AnnexinVivo increases in the tumors in response to both drugs over time.

(a)

(b)

(c)

(d)

(e)