Change of Apoptosis and Glucose Metabolism in Lung Cancer Xenografts during Cytotoxic and Anti-Angiogenic Therapy Assessed by Annexin V Based Optical Imaging and ¹⁸F-FDG-PET/CT

Figure 5

Representative TUNEL stainings of entire tumor sections. Images showing TUNEL stainings (TUNEL in red, counterstaining of nuclei by DAPI in blue) of entire sections from a representative tumor of the control group (a), the cytotoxic (carboplatin, (b)), and the anti-angiogenic (sunitinib, (c)) treatment group at day 4. In the carboplatin-treated tumor, apoptosis is only slightly higher than in the untreated control tumor. In the sunitinib-treated tumor, however, apoptosis is strongly enhanced. Bar: 1 mm.

(a)

(b)

(c)